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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Clin Cancer Res. 2013 Jan 22;19(6):1458–1466. doi: 10.1158/1078-0432.CCR-12-3306

Figure 2. Influence of Oatp1b2-deficiency on sorafenib pharmacokinetics.

Figure 2

A, B) Wildtype (WT) and Oatp1b2(-/-) female mice (n = 4/group) were given 10 mg/kg sorafenib via oral gavage. Plasma sorafenib (A) and sorafenib-glucuronide (B) concentrations were determined by LC-MS/MS. Data represent the mean ± SE (*, P<0.05; **, P<0.01).