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. Author manuscript; available in PMC: 2014 Mar 15.

Published in final edited form as: Clin Cancer Res. 2013 Jan 22;19(6):1458–1466. doi: 10.1158/1078-0432.CCR-12-3306

Table 1.

Sorafenib pharmacokinetic parameters in mice after a single oral administration of 10 mg/kg.

		Sorafenib		Sorafenib-glucuronide

Strain	Genotype	Cmax (μg/mL)	AUC (μg×h/mL)	Cmax (μg/mL)	AUC (μg×h/mL)	S-glu:Sorafenib AUC Ratio
DBA	WT	6.70±0.27	24.0±2.20	1.10±0.40	4.20±1.00	0.17±0.02
DBA	Oatp1b2(-/-)	5.10±0.50^*	18.0±2.00	6.00±1.60^*	23.0±5.60*	1.36±0.39^*
FVB	WT	5.10±0.75	23.0±4.40	0.19±0.12	0.83±0.42	0.03±0.01
FVB	Oatp1a/1b(-/-)	5.60±0.53	18.0±2.00	4.70±0.63^***	24.0±2.30^***	1.35±0.15^***
FVB	OATP1B1^tg	5.60±0.59	16.0±1.40	3.30±0.40^***	14.0±1.30^***	0.90±0.12^***
FVB	OATP1B3^tg	5.70±0.32	19.0±1.60	2.70±0.12^***	12.0±1.40^***	0.61±0.08^***

Values are mean ± SEM. Abbreviations: AUC, Area under the curve; Cmax, maximum plasma concentration; S-glu, sorafenib-glucuronide; WT, wildtype

^*

P<0.05

^***

P<0.001.