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. 2013 Mar 19;8(3):e58511. doi: 10.1371/journal.pone.0058511

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© 2013 Im et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Survival after air-breathing tests in Snx5^+/+, Snx5^+/-, and Snx5^-/- mice. Within 30 min, nearly 60% of Snx5^-/- mice had died (asterisk). (B) Appearance after air-breathing tests in E18.5 mice. Cyanotic appearance and condensed lungs in Snx5^-/- mice. (C) Body and lung weights of Snx5^+/+, Snx5^+/-, and Snx5^-/- mice. Lung weight and lung to body weight ratios of Snx5^-/- mice were decreased by 22.9% and 14.9%, respectively, relative to Snx5^+/+ mice. *P < 0.0001; data represent Snx5^+/+, n = 24; Snx5^+/-, n = 27; and Snx5^-/- mice, n = 17.