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. 2013 Mar 19;8(3):e59478. doi: 10.1371/journal.pone.0059478

Figure 4. NSE-apoE4 and apoE4-KI, but not GFAP-apoE4, mice have reduced dendritic spine density in the CA1 region compared to apoE3 counterparts at 19–21 months of age.

Figure 4

(A) Representative images of dendrites with spines from the CA1 region of NSE-apoE3, NSE-apoE4, apoE3-KI, apoE4-KI, GFAP-apoE3, or GFAP-apoE4 mouse brains. (B) Quantification of total spine density in the CA1 region, combining AO+BS spines. (C) Number of AO and BS spines in the CA1. Values are mean ± SEM, n = 28–33 neurons from 3–5 mice for each group. **p<0.01, ***p<0.001.