Figure 6. NSE-apoE4, but not GFAP-apoE4, mice have decreased spine density in the auditory cortex at 19–21 months of age.

(A) Representative images of dendrites from the auditory cortex of NSE-apoE3, NSE-apoE4, apoE3-KI, apoE4-KI, GFAP-apoE3, or GFAP-apoE4 mouse brains. (B) Quantification of total spine density in the auditory cortex, combining AO+BS spines. (C) Number of AO and BS spines in the auditory cortex. Values are mean ± SEM, n = 20–24 neurons from 3–5 mice for each group. **p<0.01.