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Group-averaged BOLD and CBF fMRI responses to 5% CO2 challenge before and after methylene blue (MB) injection in the same animals (normoxia). Two ROI’s (~6×6 pixels each) which were determined from group data of the forepaw stimulation and used in the quantitative analysis are shown. Values are in mean ± SEM (N = 8). * indicates P < 0.05 with paired t-test.
