Figure 7. Putative interactions of signature pattern 1.

The x-ray structure of gp120 [18] is shown as a cartoon with high ranking DI pairs involving signature pattern residues 309 (orange) and 317 (light blue) marked by spheres connected by bars. Most of these pairs cluster around the two residues in the V3 loop on the lower right. In addition, there are high ranking DI pairs with residues 167 and 170 (dark blue) in V2 (dashed, no x-ray structure available), and with residues 208 and 429 in the inner domain 2 and bridging sheet, respectively.