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. Author manuscript; available in PMC: 2014 Mar 18.
Published in final edited form as: Chem Res Toxicol. 2013 Feb 15;26(3):388–398. doi: 10.1021/tx300479w

Table 4.

Levels of GS-DCBN and other metabolites in nasal-wash samples from WT mice at various times following DCBN treatmenta

DCBN dose (mg/kg), route Time after injection (h) Metabolite levels (pmol/ml)b
GS-DCBN Gly-Cys- DCBN Cys- DCBN N-acetyl-Cys- DCBN
10, i.p. 0.5 1.6±0.4c 0.05±0.03 0.48±0.27d 0.57±0.11d
2 4.5±2.2c 0.15±0.12 1.0±0.96 1.1±0.85
6 1.4±1.0c 0.06±0.06 0.42±0.32 0.52±0.29
24 0.04±0.05 0.001±0.002 0.08±0.05d 0.12±0.09d
5, i.p. 0.5 0.53±0.18e 0.03±0.02 0.17±0.06 0.37±0.16e
2 1.6±0.74c 0.06±0.03 0.19±0.10 0.42±0.15
6 0.91±0.87c 0.03±0.02 0.16±0.16 0.14±0.13
24 <0.2 <0.03 <0.09 <0.28
1 × 4, s.c. 0.5 1.4±0.9 0.11±0.08f 0.39±0.20 0.36±0.10
2 0.44±0.10 0.03±0.01f 0.12±0.10 0.31±0.50
6 0.33±0.20 0.01±0.00f 0.20±0.02 0.14±0.10
24 0.03±0.03 <0.03 0.07±0.03 0.08±0.10
a

Experimental design is described in the legend to Table 3.

b

Values represent means ± S.D. (n = 3–6 for each time point). Statistical significance of differences in levels of the four metabolites at each time point was analyzed using One-way analysis of variance followed by Student-Newman-Keuls test.

c

P<0.05, compared to all other metabolites

d

P<0.05, compared to Gly-Cys-DCBN levels

e

P<0.05, compared to Cys-DCBN and Gly-Cys-DCBN levels

f

P<0.05, compared to GS-DCBN levels