Table 1.

Clinical Trials Using Cardiac Gene Transfer for CHF

Transgene	SDF-1	SDF-1	SERCA2a	SERCA2a	AC6
Trial Identifier	NCT01082094	NCT01643590	NCT00454818	NCT01643330	NCT00787059
Phase	1	2	1 and 2	2	1/2
Vector	plasmid	plasmid	AAV1	AAV1	Adenovirus
Delivery Method	Endomycardial injection	Endomycardial injection	Intracoronary injection	Intracoronary injection	Intracoronary injection
Enrollment	17	90	39	200	72
Sample Size	5 mg dose: 4 15 mg dose: 6 30 mg dose: 7	Placebo: 30 15 mg dose: 30 30 mg dose: 30	Placebo: 14 Low dose: 8 Middle dose: 8 High dose: 9	Placebo: 100 Treatment: 100	Placebo: 18 Treatment: 54 in 6 doses
Design	Open label	Randomized Double-blind Placebo-controlled	Randomized Double-blind Placebo-controlled	Randomized Double-blind Placebo-controlled	Randomized Double-blind Placebo-controlled
Status	Completed	Recruiting	Completed	Recruiting	Recruiting
Outcome	Apparently safe; Trends in improving symptoms and functions	N/A	Apparently safe; Trends in improving symptoms and functions	N/A	N/A