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. Author manuscript; available in PMC: 2014 Apr 12.
Published in final edited form as: J Mol Biol. 2013 Jan 23;425(7):1183–1197. doi: 10.1016/j.jmb.2013.01.016

Figure 2.

Figure 2

Aggregation kinetics of polyQ peptides with varying β-hairpin propensity. (a) Aggregation kinetics (HPLC sedimentation assay) showing rates of monomer disappearance for approximately 100 μM solutions of different polyQ peptides; (b) aggregation of various polyQ peptides incubated in the 10–20 μM range in PBS at 37 °C; (c) aggregation of AcWQ11pGQ11WTGK2 monitored by CD spectroscopy; (d) circular dichroism spectra of 20–30 μM freshly disaggregated monomers: K2Q10pGQ11K2 (red); K2Q25K2 (black); K2Q10pGQ11K2 – K2Q25K2 (green).