Table 2.

Summary of nucleation kinetics and fibril stability analysis

Peptides Studied	Data pointsa	Slopeb	R2 of fitc	n*d	Cre (μM)	ΔGelongf (kJ/mol)
K2Q23K2g	8	5.9	0.9875	3.9	2.9 ± 0.5	−32.9
K2Q10PGQ11K2	7	3.4	0.9197	1.4	1.7 ± 0.4	−34.3
D2Q23K2	7	3.6	0.9671	1.6	1.2 ± 0.3	−35.3
K2Q10pGQ11K2	7	2.7	0.9864	0.7	0.35 ± 0.02	−38.3
K2CQ22CK2h	5	2.8	0.9557	0.8	0.36 ± 0.03	−38.3
AcWQ22WTGK2	6	2.7	0.9593	0.7	0.21 ± 0.02	−39.6
AcWQ11pGQ11WTGK2	5	2.9	0.9664	0.9	0.11 ± 0.01	−41.3

^aNumber of data points in the log-log plot;

^bSlope of log-log plot;

^cFit of log-log plot;

^dn^* from log-log slope;

^eEquilibrium concentration of peptide from average of final positions of fibril growth and dissociation curves;

^fCalculated free energy change on elongation calculated from the C_r value ⁴⁶;

^gData for K₂Q₂₃K₂ from ²³;

^hThis is the oxidized, disulfide cross-linked form of this molecule.