Table 1. Parameter ranges used for simulated medications.
| Parameter | Description | Units | Range of Values | Incr |
| AMPA gmax | conductance of AMPA channel | % increase | 0, 20, 40, 60, 80 | 5 |
| alpha2 | conductance of GABA channel, alpha2 subtype | % increase | 0, 15, 30, 45, 60 | 5 |
| NMDA | conductance of NMDA channel1 | % increase | 0, 20, 40, 60, 80 | 5 |
| AMPA τ2 | decay time constant of AMPA channel | msec | 1, 3, 5 | 3 |
| CR proj | weight of projection of CR cells on postsynaptic targets | % increase | 0, 20, 40, 60 | 4 |
| total number of simulated trials: 1,500 | ||||
1
Resultant increase in intracellular Ca++ also induces LTP; the quantitative manner in which this is implemented is described in the text, and is in addition to the effect shown here.
Using the schizophrenic model, simulated medication trials were run, systematically varying model parameters through the ranges shown. A total of 3×5× 5×5×4 = 1,500 simulated trials were conducted. Incr = number of increments.