Table 3.
Hazard ratio for clinical events by tertiles of telomere length (in kilo-bases) and event type*
| Tertiles of telomere length | |||
|---|---|---|---|
| Longest (Reference) (n = 643) |
Middle (n = 644) |
Shortest (n = 644) |
|
| Telomere length (kilo-bases) | 5.5 to 8.2 | 5.0 to < 5.5 | 4.1 to <5.0 |
| CHD event or all-cause mortality | |||
| Number of events | 70 | 96 | 122 |
| Hazard ratio (95% CI) | 1.00 (Reference) | 1.30 (0.94–1.80) | 1.09 (0.81–1.48) |
| All-cause mortality only | |||
| Number of events | 46 | 52 | 83 |
| Hazard ratio (95% CI) | 1.00 (Reference) | 1.11 (0.73–1.69) | 1.12 (0.77–1.62) |
| Non-fatal CHD events only | |||
| Number of events | 34 | 58 | 61 |
| Hazard ratio (95% CI) | 1.00 (Reference) | 1.56 (1.00–2.41) | 1.17 (0.76–1.80) |
| Fatal CHD events only | |||
| Number of events | 4 | 8 | 11 |
| Hazard ratio (95% CI) | 1.00 (Reference) | 2.05 (0.61–6.92) | 1.79 (0.56–5.72) |
Hazard ratios are adjusted for age, sex, body mass index, Framingham risk score, use of lipid-lowering medications, physical activity, ln CRP, ln IL6, and sICAM-1.