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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Medchemcomm. 2013 Mar;4(3):564–568. doi: 10.1039/C3MD20374C

Scheme 3.

Scheme 3

Reagents and conditions: (a) MeOPhCH2MgCl, NiCl2(dppp), THF, rt, 18 h, 97%; (b) H2, PtO2, HOAc, 50 psi, rt, 36 h, 84%; (c) (S)-glycidol, EtOH, reflux, 48 h, 76%.