Scheme 3.
Reagents and conditions: (a) MeOPhCH2MgCl, NiCl2(dppp), THF, rt, 18 h, 97%; (b) H2, PtO2, HOAc, 50 psi, rt, 36 h, 84%; (c) (S)-glycidol, EtOH, reflux, 48 h, 76%.
Reagents and conditions: (a) MeOPhCH2MgCl, NiCl2(dppp), THF, rt, 18 h, 97%; (b) H2, PtO2, HOAc, 50 psi, rt, 36 h, 84%; (c) (S)-glycidol, EtOH, reflux, 48 h, 76%.