Table 1.

Analogue inhibition of [³H]DTBZ binding to rat synaptic vesicle membranes and inhibition of [³H]DA uptake into rat striatal synaptic vesicles.

Compd.	[3H]DTBZ	VMAT2 [3H]DA Uptake
	Ki ± SEM (μM)a	Ki ± SEM (μM)a
1	2.76 ± 0.64b	0.47 ± 0.045b
2	0.97 ± 0.00b	0.045 ± 0.002b
3	2.31 ± 0.21b	0.044 ± 0.008b
4	3.41 ± 0.67c	0.060 ± 0.005
5	1.87 ± 0.25c	0.087 ± 0.04
6	4.4 ± 0.76	0.34 ± 0.13
7	1.43 ± 0.136	0.17 ± 0.01
8	22.57 ± 0.23	4.49 ± 0.35
9	5.59 ± 0.94	0.51 ± 0.089
10	9.59 ± 1.47	0.18 ± 0.024
11	3.49 ± 0.63	0.68 ± 0.18
13	> 100	0.054 ± 0.042

^aEach K_i value represents data from at least three independent experiments, evaluated in duplicate;

^bdata taken from reference 10;

^cdata taken from reference 12b.