Table 6.
Number of patients with lymph node metastasis and lymphatic and vascular invasion according to the depth of tumor in the submucosal layer
| Patients with diseases | |||||||
| Lymph node metastasis | |||||||
| sm (38 studies: n = 2149)1 | sm1 (n = 308) | sm2 (n = 349) | sm3 (n = 624) | ||||
| SCC | ADC | SCC | ADC | SCC | ADC | SCC | ADC |
| 793/1779 (45%) | 95/370 (26%) | 60/224 (27%) | 8/84 (10%) | 107/296 (36%) | 11/53 (21%) | 301/544 (55%) | 39/80 (49%) |
| Lymphovascular invasion | |||||||
| sm (n = 1286)1 | sm1 (n = 134) | sm2 (n = 150) | sm3 (n = 209) | ||||
| 627/1090 (56%) | 76/196 (39%) | 58/111 (52%) | 2/23 (9%) | 88/135 (65%) | 4/15 (27%) | 118/184 (64%) | 19/25 (76%) |
| Microvascular invasion | |||||||
| sm (n = 1194)1 | sm1 (n = 104) | sm2 (n = 185) | sm3 (n = 251) | ||||
| 468/1161 (40%) | 6/33 (18%) | 19/97 (20%) | 1/7 (14%) | 67/183 (37%) | 0/2 (0%) | 114/239 (48%) | 0/12 (0%) |
1
Total numbers of patients differ since not all studies provide relevant information. sm: Submucosal layer; SCC: Squamous cell carcinoma; ADC: Adenocarcinoma.