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. 2013 Mar 19;8(3):e58838. doi: 10.1371/journal.pone.0058838

Table 2. Subgroup analyses for studies evaluating the effects of early nutrition and delayed nutrition on mortality.

Subgroups N RR (95% CI) Heterogeneity (I2)
Total 7 0.35 (0.24, 0.50) 44%
Sample size
<100 5 0.49 (0.27, 0.87) 30%
>100 2 0.28 (0.22, 0.35) 0
Publication year
<2005 3 0.54 (0.23, 1.27) 35%
>2005 4 0.29 (0.23, 0.37) 6%
Study design
RCT 4 0.62 (0.32, 1.22) 14%
NPS 3 0.28 (0.23, 0.35) 0
Starting time of early nutrition
<72 h 5 0.45 (0.24, 0.87) 56%
<7 d 2 0.26 (0.18, 0.39) 0
Compared route
Early PN vs. delayed EN 2 0.57 (0.19, 1.76) 62%
Early EN vs. delayed EN 3 0.37 (0.21, 0.68) 0
Early EN vs. no feeding 1 0.29 (0.22, 0.38) -
Unknown 1 0.24 (0.15, 0.38) -

Abbreviations: EN, enteral nutrition; N, number of studies; NPS, non-randomized prospective study; PN, parenteral nutrition; RCT, randomized controlled trial; RR, relative risk.