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(a) Measured TMZ concentrations (in µg/ µL) in cerebrospinal fluid (CSF) and blood plasma in animals treated with TMZ only (TMZ; n = 4) or combined TMZ with FUS-BBB opening (TMZ+FUS; n = 6). (b) Corresponding CSF/Plasma ratios (in %) determined from (a) (p = 0.06).
