Table 2.
Fat Pad Mass and Fractional Synthesis in 4-Month-Old WT and GRdim/dim (DIM) Mice Treated with Vehicle or DEX and Labeled With Heavy Watera
| Group | n | Inguinal Depot |
Epididymal Depot |
||||
|---|---|---|---|---|---|---|---|
| Fat Pad Mass (mg) | Fraction New TG/wk (f) | Fraction New Palmitate/wk (f) | Fat Pad Mass (mg) | Fraction New TG/wk (f) | Fraction New Palmitate/wk (f) | ||
| WT, Veh | 13 | 248 ± 78 | 0.35 ± 0.14 | 0.21 ± 0.12 | 421 ± 167 | 0.19 ± 0.06 | 0.08 ± 0.05 |
| WT, DEX | 14 | 372 ± 221 | 0.40 ± 0.16 | 0.24 ± 0.13 | 638 ± 400 | 0.25 ± 0.07b | 0.12 ± 0.07 |
| DIM, Veh | 13 | 353 ± 116 | 0.29 ± 0.16 | 0.16 ± 0.14 | 728 ± 253 | 0.15 ± 0.09 | 0.07 ± 0.10 |
| DIM, DEX | 14 | 534 ± 95c | 0.40 ± 0.09 | 0.33 ± 0.10c | 964 ± 311 | 0.29 ± 0.05d | 0.24 ± 0.07d |
Abbreviations: DIM, GRdim/dim; Pre, before treatment; Veh, vehicle.
Data are shown as mean ± sd. P values are compared with vehicle of same genotype by 2-way ANOVA followed by Bonferroni posttests.
P < .05.
P < .01.
P < .001.