Table 6.
Unbound volume of distribution in the brain (Vu,brain) determined using Sprague–Dawley (SD) rat and Naval Medical Research Institute (NMRI) mouse brain slices
| |
Ion class |
Vu,brain ml·g brain-1 |
|
|---|---|---|---|
| SD rat | NMRI mouse | ||
| Verapamil |
Base |
46.6 (1.8) |
47.3 (4.4) |
| Docetaxel |
Base |
777 (217) |
796 (177) |
| Oxycodone |
Base |
4.20 (0.13)* |
3.75 (0.22) |
| Digoxin |
Base |
33.1 (6.0) |
44.9 (5.7) |
| Gabapentin |
Zwitterion |
4.49 (0.29) |
4.22 (0.93) |
| Indomethacin |
Acid |
14.1 (1.8) |
12.0 (1.8) |
| Paroxetine |
Base |
714 (72) |
596 (97) |
| Thioridazine |
Base |
2650 (232) |
1930 (170) |
| Diazepam | Neutral | 17.8 (1.1) | 17.1 (2.3) |
* Data from Fridén et al., 2011 [6].
Data are reported as means (standard deviations).