Table 3.
Phenotypes of lipid metabolic genes inactivated by RNAi
| Sequence name | Gene name | LDs LD size | Other phenotypes | Pathway | Key references |
|---|---|---|---|---|---|
| C49F5.1 |
sams-1 |
increased |
Growth rate variant, lean, sterile |
Glycerophospholipid metabolism |
[20,21] |
| C05D11.7 |
atgl |
increased |
|
Glycerolipid metabolism |
[51,52] |
| F14F3.3 |
mboa-7 |
increased |
|
Glycerophospholipid metabolism |
[17,18] |
| C10F3.2 |
dhs-16 |
increased |
Egg laying defect, growth rate variant, lethal, slim |
Primary bile acid biosynthesis |
[50] |
| C56G2.6 |
let-767 |
increased |
Growth rate variant, slim, lethal, egg laying defect |
Steroid hormone biosynthesis,Linoleic acid metabolism,Biosynthesis of unsaturated fatty acids |
[49,53] (4) |
| H37A05.1 |
lpin-1 |
decreased |
Growth rate variant, slim, egg laying defect |
Glycerophospholipid metabolism |
[54,55] |
| C23H3.4 |
sptl-1 |
decreased |
Egg laying defect, lethal,pale |
Sphingolipid metabolism |
[16] |
| F46E10.1 |
acs-1 |
decreased |
Growth rate variant, slim, larvae arrest, lethal |
Fatty acid metabolism, Glycerophospholipid metabolism |
[56,57] |
| T19B10.1 |
cyp-29A2 |
decreased |
Egg laying defect, lethal |
Arachidonic acid metabolism |
|
| VZK822L.1 |
fat-6 |
decreased |
Growth rate variant, sterile, pale, slim |
Biosynthesis of unsaturated fatty acids |
[14,58-60] |
| T27F6.6 |
|
|
Egg laying defect |
Sphingolipid metabolism |
|
| ZC416.8 |
cha-1 |
|
Egg laying defect |
Glycerophospholipid metabolism |
[61-64] |
| K12H4.5 |
|
|
Reduced brood size, growth rate variant (l3-l4,72 h normal) |
Glycerophospholipid metabolism |
|
| F25B4.6 |
hmgs-1 |
|
Growth rate variant, larval arrest, larval lethal,sterile |
Synthesis and degradation of ketone bodies |
|
| F56D1.5 |
dhs-5 |
|
Egg laying defect |
Steroid hormone biosynthesis |
|
| T02G5.8 |
kat-1 |
|
Growth rate variant (L3,72 h normal) |
Synthesis and degradation of ketone bodies |
[65,66] |
| F32H2.5 |
fasn-1 |
|
Larval arrest, lethal |
Fatty acid synthesis |
[8,22,67] |
| W09B6.1 |
pod-2 |
|
Larval arrest, lethal |
Fatty acid synthesis |
[22,68,69] |
| F11E6.5 |
elo-2 |
|
Pale, slim |
Fatty acid synthesis |
[14,70] |
| D2024.3 |
elo-3 |
|
Pale, slim, egg laying defect |
unclear |
|
| T01E8.3 | plc-3 | Sterile | Glycerophospholipid metabolism | [71-73] |