Table 1.
CNR1 rs806378: frequency distribution of symptom phenotypes (%) among different genotypes
| IBS-C | IBS-D | IBS-A | CAP | Dyspepsia | Healthy | |
|---|---|---|---|---|---|---|
| Total number | 154 | 173 | 80 | 18 | 30 | 228 |
| CC (n = 358) | 21.2 | 29.0 | 11.7 | 2.2 | 4.5 | 31.3 |
| CT (n = 264) | 25.8 | 21.2 | 13.3 | 1.9 | 4.2 | 33.7 |
| TT (n = 61) | 16.4 | 21.3 | 4.9 | 8.2 | 4.9 | 44.3 |
There is a significant association of this CNR1 rs806378 genotype and symptom phenotype. (χ2 P = 0.027). IBS-C, constipation-predominant irritable bowel; IBS-D, diarrhea-predominant irritable bowel syndrome (IBS); IBS-A, mixed or alternating irritable bowel syndrome; CAP, chronic abdominal pain.