Fig. 1.

Short-term effect of keratinocyte growth factor-2 (KGF2) on P-glycoprotein (Pgp) activity in Caco-2 cells. Overnight serum-starved postconfluent Caco-2 cells were treated with KGF2 (10 ng/ml) in serum-free cell culture medium supplemented with 0.2% BSA for 60 min. [³H]digoxin flux (1 μM) was measured as described in materials and methods. Results are expressed as %control and represent means ± SE of 6 separate experiments performed in triplicate. *P < 0.05 compared with untreated control.