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. 2013 Jan 22;304(6):E651–E660. doi: 10.1152/ajpendo.00471.2012

Fig. 4.

Fig. 4.

Impaired GLP-1 secretion from colon tissue of α-gustducin knockout mice in response to fatty acids. A: basal GLP-1 release in glucose-free, BSA-free Hanks' buffered salt solution from colon mucosa of α-gustducin knockout (filled bar) vs. wild-type (open bar) mice. B–D: GLP-1 secretion in response to SCFAs, LCFAs, OEA, and bile acids from colon mucosa of α-gustducin knockout (filled bar) vs. wild-type (open bar) mice. Data were generated in triplicate for each mouse, with n = 3–6 mice for each genotype, and are expressed as means ± SE. Statistical significance was determined by ANOVA and Student's unpaired two-tailed t-test. *P < 0.05, **P < 0.01, and ***P < 0.001, gustducin knockout vs. wild-type mice. #P < 0.05 and ###P < 0.001, fatty acid-treated vs. basal GLP-1 release.