Table 1.

Clinical parameters

	3 mo			6 mo
	Control	Diabetes	Diabetes + apelin	Control	Diabetes	Diabetes + apelin
Glycemia, mg/dl	145 ± 8	586 ± 14*	560 ± 40*	125 ± 7	552 ± 13*	580 ± 10*
Body weight, g	27 ± 1	19 ± 1*	18 ± 1*	30 ± 1	19 ± 1*	17 ± 1*
Systolic blood pressure, mmHg	ND	ND	ND	106 ± 5	86 ± 2*	89 ± 2*
Renal apelin, pg/mg tissue	27.8 ± 0.4	17.0 ± 0.4*	28.8 ± 0.4†	22.5 ± 0.4	16.2 ± 0.3*	24.1 ± 0.4†

Values are means ± SE. Glycemia and body weight were measured at the time of death, and systolic blood pressure was recorded using the tail-cuff method in 6-mo-old the week before death.

^*P < 0.01 vs. control,

^†P < 0.01 vs. diabetes by ANOVA.