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Outline of the two protocols. A: protocol used for determining the dose-response curve for the angiotensin II (ANG II) AT1 receptor antagonist candesartan, or the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), or the combination of the two. B: protocol used for investigating the roles of AT1 and A1 receptors on the regulation of intrarenal hemodynamics and tubular Na+ handling. STZ, streptozotocin.
