Fig. 4.

Tubular effects of the in vivo intrarenal blockade of ANG II and adenosine receptors. Urine flow, fractional urinary Na⁺ excretion, fractional urinary Li⁺ excretion, transported Na⁺ and total kidney oxygen consumption of control and diabetic animals before and after blockade of AT₁ receptors by candesartan (4.2 μg/kg), A₁ receptors by DPCPX (140 μg/kg), or the combined blockade of AT₁ and A₁ receptors. Results expressed as means ± SE for n = 8–16. *P < 0.05 vs. baseline within the same group. #P < 0.05 vs. corresponding control.