Table 3.

Renal effects of the intrarenal blockade of adenosine A₁ and A₂ receptors in control and diabetic rats

	Control Rats			Diabetic Rats
	Baseline	DPCPX	DPCPX + DMPX	Baseline	DPCPX	DPCPX + DMPX
MAP, mmHg	110 ± 4	111 ± 3	109 ± 3	116 ± 3	111 ± 4*	111 ± 4*
RBF, ml/min	7.4 ± 0.3	9.7 ± 0.3*	9.6 ± 0.3*	7.8 ± 0.2	10.1.±0.2*	9.8 ± 0.3*
RVR, mmHg·min−·ml	14.9 ± 0.7	11.4 ± 0.5*	11.5 ± 0.4*	14.9 ± 0.5	11.0 ± 0.4*	11.4 ± 0.5*
GFR, ml/min	1.5 ± 0.2	2.0 ± 0.3	1.7 ± 0.2	3.7 ± 0.4‡	2.9 ± 0.2‡	2.5 ± 0.4‡
FF, %	38 ± 5	37 ± 4	33 ± 3	72 ± 9‡	53 ± 5*	54 ± 10‡
Urine flow, μl/min	5 ± 1	16 ± 2*	8 ± 1†	24 ± 4‡	38 ± 7*‡	28 ± 4†‡
TNa, %	200 ± 26	264 ± 37	228 ± 31	507 ± 59‡	396 ± 31‡	391 ± 61‡
FENa, %	0.1 ± 0.0	1.3 ± 0.2*	0.7 ± 0.1*†	0.3 ± 0.1‡	1.4 ± 0.3*	1.3 ± 0.3*‡

Results are expressed as means ± SE for n = 6–8. Effects during baseline and after blockade of A₂ receptors by 3,7-dimethyl-1-propargylxanthine (DMPX; 0.5 mg/kg) superimposed on prior A₁ receptor blockade by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 140 μg/kg).

^*P < 0.05 vs. baseline within the same group.

^†P < 0.05 vs. DPCPX within the same group.

^‡P < 0.05 vs. corresponding control.