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. 2012 Dec 26;304(5):F451–F462. doi: 10.1152/ajprenal.00639.2011

Fig. 8.

Fig. 8.

Effect of PDBu on normal DSM strips with and without iberiotoxin (IBTX). A: normal control muscle strip without PDBu or IBTX. B: effect of PDBu (10 nM) on spontaneous contractions in DSM strip. Arrows indicate the addition of PDBu. In C, the muscle strip is first preincubated with 1.0 μM IBTX for 45 min after which 10.0 nM PDBu is added (arrow). D: summary data for the effect of PDBu on frequency and amplitude with and without IBTX. In B, PDBu resulted an increase in frequency to 148 ± 21.4% (P < 0.05; n = 6) and a decrease in amplitude to 25 ± 3.9% (P < 0.05; n = 6), both of which were significantly different (*) from control (A). In C, the PDBu response after preincubation with IBTX was 115 ± 13.6% (P = 0.061; n = 6) for frequency and 84 ± 11.7% (P = 0.067; n = 6) for amplitude, both of which were not significantly different from control (A).