Fig. 5.
KLF2 overexpressing mice have decreased stroke volume and BBB permeability. A: TTC staining of KLF2 overexpressing (K2tg) and control brains after 1 h tMCAO and 48 h reperfusion. Representative results shown. B: quantitative analysis of stroke volume (n = 8 to 9/group). *P = 0.004 vs. control. C: quantitative PET assessment of radiotracer uptake in K2tg and control brains at baseline and after stereotactic injection of TNF-α into the cerebral cortex (n = 3/group). D: quantification of EBD permeability in K2tg and control brains after sham or stereotactic injection of TNF-α (n = 3/group). *P = 0.03; #P = 0.003.