Table 1.
SLC27 family of transport proteins
| Human gene name | Protein name | Aliases | Predominant substrates | Transport type/coupling ions | Tissue distribution and cellular/subcellular expression | Link to disease | Human gene locus | Sequence accession ID (RefSeq) | Splice variants and their features |
|---|---|---|---|---|---|---|---|---|---|
| SLC27A1 | FATP1 | FATP, ACSVL5 | LCFA, VLCFA | LCFA transport, VLCFA activation | BAT, WAT, heart, skeletal muscle, skin, brain, kidney, endothelial cells | Unknown | 19p13.11 | NM_198580.1 | Unknown |
| SLC27A2 | FATP2 | ACSVL1, VLCS, VLACS, FACVL1 | LCFA, VLCFA | LCFA transport, VLCFA activation | Liver, kidney cortex, placenta | Unknown | 15q21.2 | NM_003645.3 (Variant 1), NM_001159629.1 (Variant 2) | Variant 1 encodes the full-length protein; Variant 2 lacks an in-frame coding exon, resulting in a shorter isoform missing an internal protein segment |
| SLC27A3 | FATP3 | ACSVL3, VLCS-3 | LCFA, VLCFA | LCFA transport, VLCFA activation | Skin, adrenal gland, testis, ovary, brain, lung, endothelial cells | Unknown | 1q21.3 | NM_024330.1 | Unknown |
| SLC27A4 | FATP4 | ACSVL4 | LCFA, VLCFA | LCFA transport, VLCFA activation | Small intestine, skin, placenta, brain, skeletal muscle, WAT, endothelial cells | Restrictive dermopathy (OMIM #275210) | 9q34.11 | NM_005094.3 | Unknown |
| SLC27A5 | FATP5 | ACSVL6, VLCS-H2, VLACSR, FACVL3, BAL, ACSB, BACS | LCFA, bile acids | LCFA transport, bile acid conjugation | Liver | Unknown | 19q13.43 | NM_012254.2 | Unknown |
| SLC27A6 | FATP6 | ACSVL2, VLCS-H1, FACVL2 | LCFA, VLCFA | LCFA transport, VLCFA activation | Heart, skin | Unknown | 5q23.3 | NM_014031.3 (Variant 1), NM_001017372.1 (Variant 2) | Variant 2 has an additional segment in the 5’ UTR but encodes the same protein as variant 1 |
LCFA: Long-chain fatty acid
VLCFA: Very long-chain fatty acid
BAT: Brown adipose tissue
WAT: White adipose tissue