Table 1.
The human members of the organic anion transporting superfamily
| New gene symbol | New protein name | Predominant substrates | Tissue distribution/subcellular expression | Link to disease | Human gene locus | Sequence Accession ID | Splice variants |
|---|---|---|---|---|---|---|---|
| SLCO1A2 | OATP1A2 | Bile salts, organic anions and cations | Brain (endothelial cells), kidney (apical), intestine (apical), liver (cholangiocytes), eye (ciliary body) | 12p12 |
NM_021094 NM_134431 |
2 | |
| SLCO1B1 | OATP1B1 | Bile salts, organic anions | Liver (hepatocytes) | (Statin-induced myopathy, Rotor Syndrome) | 12p | NM_6446 | |
| SLCO1B3 | OATP1B3 | Bile salts, organic anions | Liver (hepatocytes) | (Unconjugated hyperbilirubinemia, Rotor syndrome) | 12p12 | NM_019844 | |
| SLCO1C1 | OATP1C1 | T4,T3, rT3, BSP | Brain (blood-brain barrier), testis (Leydig cells) | (Hyperthyroidism) | 12p12.2 |
NM_017435 NM_001145944 NM_001145945 NM_001145946 |
4 |
| SLCO2A1 | OATP2A1 | Prostaglandins | Ubiquitous | 3q21 | NM_005630 | ||
| SLCO2B1 | OATP2B1 | E-3-S, DHEAS, BSP | Liver (hepatocytes), placenta, intestine (apical), eye (ciliary body) | 11q13 |
NM_007256 NM_001145211 NM_001145212 |
3 | |
| SLCO3A1 | OATP3A1 | E-3-S, prostaglandin | Testis, heart, brain, ovary | 15q26 |
NM_013272 NM_001145044 |
2 | |
| SLCO4A1 | OATP4A1 | Taurocholate, T3, prostaglandin | Ubiquitous | 20q13.33 | NM_016354 | ||
| SLCO4C1 | OATP4C1 | Digoxin, ouabain, thyroid hormones, methotrexate | Kidney (basolateral) | 5q21.2 | NM_180991 | ||
| SLCO5A1 | OATP5A1 | 8q13.3 |
NM_030958 NM_001146008 NM_001146009 |
3 | |||
| SLCO6A1 | OATP6A1 | Testis | 5q21.1 | NM_173488 |