Table 2.
SLC15 - Proton oligopeptide cotransporter family
| Human gene name |
Protein name |
Aliases | Predominant substrates | Transport type / coupling ions |
Tissue distribution and cellular / subcellular expression |
Link to disease | human gene locus |
Sequence accession ID |
|---|---|---|---|---|---|---|---|---|
| SLC15A1 | PEPT1 | oligopeptide transporter 1, H+- peptide transporter 1 |
di- and tri-peptides, protons, beta-lactam antibiotics |
C / H+ | apical surface of epithelial cells from small intestine and kidney; pancreas, bile duct and liver |
inflammatory bowel disease (Ser117Asn SNP and colonic upregulation) |
13q32.3 | NM_005073 |
| SLC15A2 | PEPT2 | oligopeptide transporter 2, H+- peptide transporter 2 |
di- and tri-peptides, protons, beta-lactam antibiotics |
C / H+ | apical surface of epithelial cells from kidney and choroid plexus; neurons, astrocytes (neonates), lung, mammary gland, spleen, enteric nervous system |
Lead exposure (*2 haplotype associated with higher blood lead burden in male children) |
3q21.1 | NM_021082 |
| SLC15A3 | PHT2 | peptide/histidine transporter 2, PTR3 |
di- and tri-peptides, protons, histidine |
C / H+ | lung, spleen, thymus, intestine (faintly in brain, liver, adrenal gland, heart) |
11q12.2 | NM_016582 | |
| SLC15A4 | PHT1 | peptide/histidine transporter 1, PTR4 |
di- and tri-peptides, protons, histidine |
C / H+ | brain, eye, intestine (faintly in lung and spleen) |
inflammatory bowel disease (colonic upregulation) |
12q24.32 | NM_145648 |