Fig. 3.

Panels (a) and (b)  show representative images of MF illustrating RCM features of spongiosis. Panel (a) was obtained at the granular-spinous layer, demonstrating dark areas of low refractility (asterisk), in which the delineation of the single cells and the overall honeycomb appearance of the epidermis is disrupted. Panel (b) shows a similar aspect (asterisk); furthermore, single keratinocytes with prominence of bright cytoplasm are noted (red arrowheads). Panel (c) shows normal granular layer of the epidermis with skin folds (asterisk) and, (d) illustrates typical honeycomb pattern of the spinous cell layer.