Table 4.

Results of sensitivity/specificity analysis for RCM parameters are shown. Table presents ranking in order of 1) highest sensitivity 2) highest specificity, from scoring of investigator 1 (INV I). Only data with relevant reproducibility have been included in the analysis. Data are expressed as % of all examined cases. A $p$-value 0.05 was considered significant (Pearson ${\mathrm{Chi}}^2$ Test).

RCM parameter	SpecInv I	SensInv I	$p$-value Inv I	Spec Inv II	Sens- Inv II	$p$-value Inv II
Spongiosis	88.9%	94.7%	0.0001	77.8	100	0.0001
Loss of demarcation	88.9%	94.7%	0.0001	77.8	94.7	0.0001
Disarray of epidermis	77.8%	89.5%	0.0001	77.8	100	0.0001
Hyporefractile rings	88.9%	78.9%	0.001	100	84.2	0.0001
Junctional atypical lymphocytes	100%	73.7%	0.0001	100	84.2	0.0001
Vesicle-like structures (Pautrier’s microabcesses)	100%	73.7%	0.0001	88.9	52.6	0.036
Epidermal atypical lymphocytes	100%	73.7%	0.0001	100	68.4	0.001
Blood vessel dilatation	77.8%	57.9%	0.077	100	78.9	0.0001
Dendritic cells	100%	52.6%	0.007	100	36.8	0.035