Fig. 5.
Effect of leptin receptor antagonist (LA) infusion on plasma ACTH1–39 (A) and cortisol (B) in control and LTH fetuses. A: Saline-infused LTH fetuses exhibited elevated (*P < 0.05) ACTH1–39 compared with normoxic saline-infused fetuses at both day 2 and day 5 of the study. ACTH1–39 was not different in LA-infused fetuses for either group on either day 2 or 5. On day 5 of the study (96 h of LA treatment), ACTH1–39 had declined to levels not different from normoxic control saline fetuses. B: both control and LTH fetuses (LA and saline infused) exhibited the normal ontogenic, late gestation, and rise in plasma cortisol (P < 0.05 gestational age effect). LA infusion did not alter this increase in either group. Values represent mean values ± SE.