Table 4.
Results of the parent-of-origin analyses.
Transmission asymmetry test (TAT) |
PO-LRT |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mothers |
Fathers |
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Single nucleotide polymorphism |
Minor allelea |
T | NT | RR | 95% CI |
P- value |
T | NT | RR | 95% CI |
P- value |
P TAT | RR |
P- value |
rs523349 in SRD5A2 | G | 81 | 80 | 1.0 | 0.7, 1.4 | 0.94 | 66 | 81 | 0.8 | 0.6, 1.1 | 0.22 | 0.34 | 1.18 | 0.27 |
rs6932902 in ESR1 | A | 79 | 43 | 1.8 | 1.3, 2.7 | 1×10−3 | 58 | 53 | 1.1 | 0.8, 1.6 | 0.64 | 0.05 | 1.61 | 0.07 |
rs2987983 in ESR2 | G | 59 | 95 | 0.6 | 0.5, 0.9 | 4×10−3 | 64 | 82 | 0.8 | 0.6, 1.1 | 0.14 | 0.33 | 0.76 | 0.27 |
rs11119982 in ATF3 | T | 83 | 71 | 1.2 | 0.9, 1.6 | 0.33 | 111 | 70 | 1.6 | 1.2, 2.1 | 3×10−3 | 0.17 | 0.79 | 0.25 |
CI, confidence interval; NT, minor allele not transmitted; PO-LRT, parent-of-origin likelihood ratio test; RR, relative risk; T, minor allele transmitted; TAT, transmission asymmetry test;
the least frequent allele in the parents.