Supplementary Table 1. Studies considered for primary analyses.

Author (Reference)	No. of isolates	Location	Children	Shigella resistance			S. flexneri resistance			S. sonnei resistance
				Gm	Km	Am	Gm	Km	Am	Gm	Km	Am
Sivapalasingam et al. 2006[31]	4432	USA		X	X	X	X	X	X	X	X	X
Wong et al. 2010[22]	616	New York, USA		X			X			X
Al-Nimri et al. 2009[32]	42	California, USA			X
Drews et al. 2010[33]	316	Alberta, Canada								X
Merino et al. 2004[34]	132	Argentina					X			X
Peirano et al. 2006[35]	306	Brazil		X		X
Mota et al. 2010[36]	28	Uruguay		X			X			X
Haukka and Siitonen 2008[37]	228	Finland		X			X			X
Nógrády et al. 2009[38]	252	Hungary		X	X
Sire et al. 2008[39]	164	Daker, Senegal		X			X			X
Putnam et al. 2004[40]	58	Egyptian	X	X		X	X		X	X		X
Mache 2001[14]	77	Ethiopia	X	X	X		X	X		X	X
Yismaw et al. 2008[41]	214	Ethiopia		X
Tiruneh 2009[42]	90	Ethiopia		X			X			X
Opintan and Newman 2007[43]	24	Ghana		X		X
Djie-Maletz et al. 2008[44]	5	Ghana	X	X		X
Urio et al. 2001[45]	46	Gaborone, Botswana	X	X			X			X
Iwalokun et al. 2001[46]	62	Nigeria		X			X			X
Udo and Eja 2004[47]	123	Calabar, Nigeria	X	X
Davies and Karstaedt 2008[48]	34	Soweto		X		X
Temu et al. 2007[49]	69	Mwanza,Tanzania		X			X
Moyo et al. 2011[50]	15	Tanzania	X	X			X
Samie et al. 2009[51]	51	Vhembe		X
Yu et al. 2007[15]	459	China		X
Zhu et al. 2011[52]	58	Henan		X			X
Ding et al. 2005[53]	290	Shanghai, China		X			X			X
Zhu et al. 2009[54]	215	Shanghai, China				X			X			X
Gu et al. 2008[27]	26	Nanjing, China		X		X
Wang et al. 2005[55]	331	Hebei, China		X			X			X
Xia et al. 2011[19]	87	Henan, China					X
Jones et al. 2004[56]	90	Amazn river basin		X
Navaneeth et al. 2001[57]	12	Bangalore, India		X			X			X
Rahman et al. 2007[58]	266	Bangalore, India		X			X			X
Bercion et al. 2008[59]	47	Bangui		X
Ashkenazi et al. 2003[60]	617	Israel		X			X			X
Niyogi et al. 2001[61]	34	India	X	X			X			X
Dutta et al. 2002[62]	101	India		X		X
Taneja et al. 2004[63]	54	India		X		X	X		X	X		X
Uppal et al. 2004[64]	56	Delhi, India	X	X			X			X
Mamatha et al. 2007[65]	68	India		X
Nandy et al. 2010[66]	516	Kolkata, India		X		X
MoezArdalan et al. 2003[67]	98	Tehran, Iran		X	X	X	X	X	X	X	X	X
Nowroozi et al. 2006[68]	142	Iran	X				X
Farshad et al. 2006[69]	82	Iran	X	X		X	X		X	X		X
Ranjbar et al. 2009[70]	200	Iran			X	X
Hamedi 2009[71]	98	Iran	X	X		X
Ashtiani et al. 2009[72]	1571	Tehran, Iran		X	X	X
Pourakbari et al. 2010[73]	682	Tehran, Iran	X	X	X	X
Soltan Dallal et al. 2011[74]	84	Tehran, Iran						X	X
Izumiya et al. 2009[75]	195	Japan								X	X
Hirose et al. 2005[76]	58	Japan									X
Ahmed et al. 2006[77]	21	Hiroshima, Japan			X			X			X
Oh et al. 2003[78]	67	Korea									X
Seol et al. 2006[79]	110	Korea								X	X
Jin et al. 2010[80]	66	Seoul, Korea								X
Jamal et al. 2010[81]	142	Kuwait& Arab		X		X
Wilson et al. 2006[19]	66	Pokhara, Nepal		X			X			X
Abu Elamreen et al. 2007[82]	6	Gaza,Palestine	X	X		X
Abu Elamreen et al. 2008[28]	28	Gaza,Palestine	X	X		X
Chompook et al. 2005[25]	144	Saraburi,Thailand		X	X	X	X	X	X	X	X	X
Banajeh et al. 2001[83]	25	Yemen	X	X
Al-Moyed et al. 2006[84]	105	Saraburi, Yemen		X
Meng et al. 2011[85]	41	Cambodia	X	X
Debdutta Bhattacharya, et al. 2012[86]	33	Andaman Islands, India		X		X
Zhang W et al. 2011[87]	230	china		X			X			X
Shiferaw B, et al. 2012[88]	1118	USA		X	X		X	X		X	X
Shamsizadeh A, et al. 2012[89]	154	Iran	X	X
Tajbakhsh M, et al. 2012[90]	37	Tehran,Iran		X			X			X

Gm: Gentamicin; Km: Kanamycin; Am: Amikacin.