Table II.
Composition of NK cell products.
| Transplant pairs | Donor’s KIR genotyping | Donor’s uninhibited receptor | Cell dose × 106 cells/kg)
|
Missing donor KIR ligand in recipient | |||
|---|---|---|---|---|---|---|---|
| MNC | NK cells | Alloreactive NK cells (%) | CD3 | ||||
| 1 | 2DL1, 2DL3, 3DL1 | 3DL1 | 36.8 | 2.7 | 0.3 (11.1) | 0.02 | HLA-Bw4 |
| 2 | 2DL1, 2DL2/3, 3DL1 | 2DL1 | 100.1 | 11.4 | 1.5 (13.1) | 0.05 | HLA-C2 |
| 3 | 2DL1, 2DL3, 3DL1 | 2DL1 | 39.5 | 11.7 | 1.0 (8.5) | 0.06 | HLA-C2 |
| 4 | 2DL1, 2DL3, 3DL1 | 3DL1 | 95.5 | 10.1 | 0.3 (3.0) | 0.06 | HLA-Bw4 |
| 5 | 2DL1, 2DL3, 3DL1 | 2DL1 | 273.2 | 92.0 | 25.5 (28) | 0.08 | HLA-C2 |
| 6 | 2DL1, 2DL2, 3DL1 | 2DL1 | 95.1 | 13.3 | 2.2 (16.9) | 0.08 | HLA-C2 |
| 7 | 2DL1, 2DL2, 3DL1 | 2DL1 | 102.0 | 20.1 | 0.0 (0) | 0.07 | HLA-C2 |
| 8 | 2DL1, 2DL3, 3DL1 | 2DL1 | 150.2 | 37.2 | 20.5 (55.4) | 0.01 | HLA-C2 |
| 9 | 2DL1, 2DL3, 3DL1 | 2DL1 | 173.3 | 26.7 | 4.7 (17.6) | 0.04 | HLA-C2 |
| 10 | 2DL1, 2DL2/3, 3DL1 | 2DL1, 3DL1 | 53.4 | 9.8 | 1.8 (18.3) | 0.00 | HLA-C2 and HLA-Bw4 |
Combined numbers for the two aphaeresis products of each donor are depicted.
NK, natural killer; KIR, killer immunoglobulin-like receptor; MNC, mononuclear cells; D, domains; L, long cytoplasmic tail; HLA, human leucocyte