Table 2.
Incidence of Age-related Macular Degeneration Outcomes by Age and Genetic Risk in the Beaver Dam Eye Study, 1988–2010.
| Outcome* and Genetic Risk† | Overall | Age (years)
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 43–54 | 55–64 | 65–74 | 75–84 | ≥ 85 | ||||||||
|
| ||||||||||||
| N at risk | N (%)events | N at risk | N (%)events | N at risk | N (%)events | N at risk | N (%)events | N at risk | N (%)events | N at risk | N (%)events | |
|
|
||||||||||||
| Early AMD | ||||||||||||
| Overall | 6840 | 624 (9.1) | 1567 | 62 (4.0) | 2503 | 147 (5.9) | 2018 | 251 (12.4) | 700 | 143 (20.4) | 52 | 21 (40.4) |
| Low | 4543 | 381 (8.4) | 998 | 40 (4.0) | 1621 | 76 (4.7) | 1383 | 155 (11.2) | 502 | 96 (19.1) | 39 | 14 (35.9) |
| Intermediate | 1848 | 180 (9.7) | 458 | 19 (4.2) | 704 | 45 (6.4) | 509 | 74 (14.5) | 166 | 37 (22.3) | 11 | 5 (45.5) |
| High | 449 | 63 (14.0) | 111 | 3 (2.7) | 178 | 26 (14.6) | 126 | 22 (17.5) | 32 | 10 (31.3) | 2 | 2 (100.0) |
| Drusen size >125 μm | ||||||||||||
| Overall | 7396 | 646 (8.7) | 1648 | 56 (3.4) | 2680 | 153 (5.7) | 2187 | 261 (11.9) | 813 | 153 (18.8) | 68 | 23 (33.8) |
| Low | 4887 | 386 (7.9) | 1047 | 39 (3.7) | 1717 | 74 (4.3) | 1483 | 152 (10.3) | 588 | 105 (17.9) | 52 | 16 (30.8) |
| Intermediate | 2011 | 189 (9.4) | 485 | 14 (2.9) | 765 | 52 (6.8) | 562 | 83 (14.8) | 185 | 35 (18.9) | 14 | 5 (35.7) |
| High | 498 | 71 (14.3) | 116 | 3 (2.6) | 198 | 27 (13.6) | 142 | 26 (18.3) | 40 | 13 (32.5) | 2 | 2 (100.0) |
| Soft indistinct drusen | ||||||||||||
| Overall | 7627 | 473 (6.2) | 1664 | 33 (2.0) | 2768 | 98 (3.5) | 2275 | 194 (8.5) | 845 | 129 (15.3) | 75 | 19 (25.3) |
| Low | 5017 | 269 (5.4) | 1058 | 21 (2.0) | 1766 | 46 (2.6) | 1535 | 109 (7.1) | 602 | 80 (13.3) | 56 | 13 (23.2) |
| Intermediate | 2091 | 149 (7.1) | 487 | 10 (2.1) | 798 | 32 (4.0) | 591 | 68 (11.5) | 198 | 35 (17.7) | 17 | 4 (23.5) |
| High | 519 | 55 (10.6) | 119 | 2 (1.7) | 204 | 20 (9.8) | 149 | 17 (11.4) | 45 | 14 (31.1) | 2 | 2 (100.0) |
| Any pigmentary abnormality | ||||||||||||
| Overall | 7893 | 548 (6.9) | 1638 | 33 (2.0) | 2755 | 105 (3.8) | 2436 | 206 (8.5) | 966 | 176 (18.2) | 98 | 28 (28.6) |
| Low | 5207 | 315 (6.1) | 1046 | 18 (1.7) | 1776 | 55 (3.1) | 1638 | 113 (6.9) | 678 | 113 (16.7) | 69 | 16 (23.2) |
| Intermediate | 2132 | 164 (7.7) | 475 | 11 (2.3) | 775 | 31 (4.0) | 627 | 71 (11.3) | 232 | 43 (18.5) | 23 | 8 (34.8) |
| High | 554 | 69 (12.5) | 117 | 4 (3.4) | 204 | 19 (9.3) | 171 | 22 (12.9) | 56 | 20 (35.7) | 6 | 4 (66.7) |
| Late AMD | ||||||||||||
| Overall | 8814 | 140 (1.6) | 1741 | 2 (0.1) | 2992 | 9 (0.3) | 2745 | 47 (1.7) | 1204 | 66 (5.5) | 132 | 16 (12.1) |
| Low | 5772 | 52 (0.9) | 1109 | 1 (0.1) | 1908 | 0 (0.0) | 1832 | 12 (0.7) | 832 | 30 (3.6) | 91 | 9 (9.9) |
| Intermediate | 2398 | 50 (2.1) | 509 | 0 (0.0) | 851 | 5 (0.6) | 710 | 21 (3.0) | 296 | 20 (6.8) | 32 | 4 (12.5) |
| High | 644 | 38 (5.9) | 123 | 1 (0.8) | 233 | 4 (1.7) | 203 | 14 (6.9) | 76 | 16 (21.1) | 9 | 3 (33.3) |
| Pure geographic atrophy | ||||||||||||
| Overall | 8775 | 49 (0.6) | 1743 | 0 (0.0) | 2992 | 3 (0.1) | 2730 | 15 (0.6) | 1179 | 22 (1.9) | 131 | 9 (6.9) |
| Low | 5770 | 21 (0.4) | 1109 | 0 (0.0) | 1910 | 0 (0.0) | 1832 | 4 (0.2) | 826 | 11 (1.3) | 93 | 6 (6.5) |
| Intermediate | 2383 | 17 (0.7) | 512 | 0 (0.0) | 851 | 1 (0.1) | 704 | 9 (1.3) | 286 | 6 (2.1) | 30 | 1 (3.3) |
| High | 622 | 11 (1.8) | 122 | 0 (0.0) | 231 | 2 (0.9) | 194 | 2 (1.0) | 67 | 5 (7.5) | 8 | 2 (25.0) |
| Exudative AMD | ||||||||||||
| Overall | 8867 | 91 (1.0) | 1742 | 2 (0.1) | 2998 | 6 (0.2) | 2753 | 32 (1.2) | 1234 | 44 (3.6) | 140 | 7 (5.0) |
| Low | 5798 | 31 (0.5) | 1109 | 1 (0.1) | 1911 | 0 (0.0) | 1835 | 8 (0.4) | 846 | 19 (2.3) | 97 | 3 (3.1) |
| Intermediate | 2416 | 33 (1.4) | 510 | 0 (0.0) | 854 | 4 (0.5) | 713 | 12 (1.7) | 306 | 14 (4.6) | 33 | 3 (9.1) |
| High | 653 | 27 (4.1) | 123 | 1 (0.8) | 233 | 2 (0.9) | 205 | 12 (5.9) | 82 | 11 (13.4) | 10 | 1 (10.0) |
AMD, age-related macular degeneration.
*
In worse eye.
†
Genetic risk groups: Low=0–1 risk alleles; intermediate=2 risk alleles; high=3–4 risk alleles.