Fig. 4.

Effects of zolmitriptan verified in a rat model of SCI. A: monosynaptic reflex (Mono) recorded from a ventral root of a chronically spinalized rat that did not display a polysynaptic reflex response. B: monosynaptic reflex from A following 300 nM bath application of zolmitriptan (+Zolm). C: short-latency polysynaptic reflex (SPR) recorded from a ventral root of a different chronically injured rat (no monosynaptic response was evoked). D: polysynaptic reflex from C after 300 nM application of zolmitriptan (modified from Fig. 5 in Murray et al. 2011). E and F: overlays of 6 SPRs recorded from TA in a SCI participant (subject 3M in Table 1) before (E) and 120 min after (F) 10 mg of oral zolmitriptan. In A–F, asterisks mark time of single pulse, or start of multiple pulse, stimulation.