. Author manuscript; available in PMC: 2013 Oct 1.

Published in final edited form as: Int J Clin Rheumtol. 2012 Dec;7(6):651–659. doi: 10.2217/ijr.12.64

Table 4.

Hematologic findings and proteins

Hematologic findings	Clinical correlation
Normocytic–microcytic anemia	Prevalence of renal involvement, cutaneous vasculitis, peripheral neuropathy Presence of ANA, RF, cryoglobulinemia and hypocomplementemia
Lymphopenia	Significantly associated at diagnosis with an increased risk of lymphoma
Monoclonal gammopathy	Associated with EGMs and risk of lymphoproliferative disease
Polyclonal hypergammaglobulinemia	Higher prevalence of extraglandular manifestations and B-cell lymphoma
Hypogammaglobulinemia	Associated with lymphoproliferative syndromes, humoral immunodeficiency
Erythrocyte sedimentation rate (>50 mm/h)	Thyroiditis, renal disease, peripheral neuropathy, cutaneous vasculitis Anti-SSB/La, RF, cryoglobulinemia and hypocomplementemia
B2 microglobulin	Useful method for estimating the degree of lymphocytic infiltration Possible evolution marker of lymphoproliferation
Soluble receptor IL-2	Possible evolution marker for lymphoma

ANA: Antinuclear antibodies; EGM: Extraglandular manifestation; RF: Rheumatoid factor.