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. Author manuscript; available in PMC: 2013 Mar 20.
Published in final edited form as: J Immunol. 2010 Nov 5;185(12):7663–7670. doi: 10.4049/jimmunol.1001707

FIGURE 7. MM218 inhibits in vitro CD4+ T cell migration in response to extracellular cyclophilins.

FIGURE 7

(A) Activated CD4+ T cells were generated in vitro and set up in Boyden chambers using recombinant CypA and CypB ± MM218. RANTES was used as a positive control for T cell chemotaxis. Data show mean ± SE chemotactic indices for each group (n=6 wells per group). Student’s t-test established ** P<0.01 and *** P<0.001 levels of statistical differences between + MM218 and no MM218 for CypA and CypB stimulation, respectively. (B) The same assay was used with activated CD4+ T cells set up either with RANTES or CypA ± MM218. Data show mean ± SE chemotactic indices for each group (n=6 wells per group). Student’s t-test established a *** P<0.001 statistical difference between + MM218 and no MM218 for CypA stimulation only. These data are representative of 3 independent experiments.