Table 1A.

Descriptive characteristics of study subjects included in the discovery study

Symptomatic knee OA*	n=600	“ROA/Pain”
Age, years mean (SD)	60.5 (8.3)
Gender, % female	61.7%
BMI kg/m2 mean (SD)	32.4 (7.2)
WOMAC mean (SD)	9.2 (4.1)
Asymptomatic knee OA*	n= 156	“ROA/No Pain”
Age, years mean (SD)	61.3 (5.5)
Gender, % female	57.7%
BMI kg/m2 mean (SD)	27.3 (4.4)
WOMAC mean (SD)	NA
No radiographic knee OA	n= 276	“No ROA/No Pain”
No pain
Age, years mean (SD)	59.2 (4.2)
Gender, % female	77.9%
BMI kg/m2 mean (SD)	25.1 (3.7)
WOMAC mean (SD)	NA

Table 1B. Descriptive characteristics of study subjects included in the meta-analysis
	Discovery	GOAL	COS	Chingford
Symptomatic knee OA**	n=352	n=1569	n=85	n=62
Age, years mean (SD)	62.8 (9.0)	68.4 (7.2)	65.6 (8.3)	65.7(5.8)
Gender, % female	61.4%	49.1%	66.7%	100%
BMI kg/m2 mean (SD)	32.7(6.8)	30.8 (5.4)	29.1 (5.1)	26.7 (3.4)
WOMAC mean (SD)	10(3.1)	5.3 (4.7)	N/A	N/A
CC	6.3%	7.5%	7.6%	9.7%
CT	40.9%	42.0%	42.4%	37.1%
TT	52.8%	50.5%	50.0%	53.2%
Asymptomatic knee OA**	n= 127	n=298	n=92	n=157
Age, years mean (SD)	61.4(5.7)	67.7 (7.3)	64.0 (9.8)	65.7(5.9)
Gender, % female	59.8%	43.0%	54.6%	100%
BMI kg/m2 mean (SD)	27.5 (4.6)	28.5 (4.9)	26.1 (4.7)	26.2 (4.4)
WOMAC mean (SD)	N/A	0.6(1.8)	N/A	N/A
CC	21.3%	9.6%	12.0%	12.3%
CT	35.4%	47.4%	48.2%	35.2%
TT	43.3%	43.0%	39.8%	52.5%
No radiographic knee OA no pain	n=296	n=743	N/A	n=527
Age, years mean (SD)	59.3 (4.2)	67.7 (7.3)	N/A	62.9 (5.7)
Gender, % female	76.0%	43.0%		100%
BMI kg/m2 mean (SD)	25.2 (3.7)	28.5 (4.9)	N/A	24.7 (3.6)
WOMAC mean (SD)	N/A	0.6(1.8)	N/A	N/A
CC	14.6%	7.3%	N/A	9.3%
CT	42.3%	39.8%	N/A	41.0%
TT	43.1%	52.9%	N/A	49.7%

^*radiographic knee OA defined as K/L ≥ 1

^**radiographic knee OA defined as K/L ≥ 2