Table 1.
Results of the KEGG pathway analysis of the T. gondii host/pathogen interactome (host genes): Immune and defence pathways, Diseases and other infections. The number of genes recovered in each pathway is in brackets and the enrichment P value from the CPDB analysis, provided where available, and significant values highlighted in bold.
| Number of genes |
P value | |
|---|---|---|
| Immune and defence | ||
| Cytokine-cytokine receptor interaction | (103) | 2.02E − 20 |
| Chemokine signalling pathway | (64) | 3.19E − 09 |
| Toll-like receptor signalling pathway | (52) | 9.24E − 17 |
| Phagosome | (47) | 1.02E − 05 |
| Natural killer cell mediated cytotoxicity | (46) | 2.73E − 07 |
| T cell receptor signalling pathway | (45) | 1.52E − 10 |
| Hematopoietic cell lineage | (42) | 1.52E − 12 |
| Leukocyte transendothelial migration | (36) | 0.000149 |
| NOD-like receptor signalling pathway | (34) | 9.21E − 14 |
| Fc epsilon RI signalling pathway | (29) | 0.000764 |
| Fc gamma R-mediated phagocytosis | (29) | 0.00115 |
| Complement and coagulation cascades | (28) | 5.80E − 07 |
| B cell receptor signalling pathway | (28) | 1.01E − 05 |
| Lysosome | (27) | |
| Antigen processing and presentation | (26) | 5.34E − 05 |
| Salivary secretion | (26) | |
| Adipocytokine signalling pathway | (25) | 0.000221 |
| RIG-I-like receptor signalling pathway | (23) | 0.000354 |
| Cytosolic DNA-sensing pathway | (22) | 0.000106 |
| Intestinal immune network for IgA production | (22) | 7.87E − 07 |
|
| ||
| Diseases | ||
| Pathways in cancer | (94) | 2.67E − 08 |
| Transcriptional misregulation in cancer | (52) | 3.32E − 06 |
| Prostate cancer | (34) | 6.94E − 06 |
| Small cell lung cancer | (31) | 4.04E − 06 |
| Colorectal cancer | (23) | 3.33E − 05 |
| Pancreatic cancer | (21) | 0.0019 |
| Acute myeloid leukaemia | (21) | 8.14E − 05 |
| Chronic myeloid leukaemia | (20) | 0.00747 |
| Glioma | (19) | 0.00964 |
| Renal cell carcinoma | (17) | |
| Endometrial cancer | (16) | 0.0048 |
| Non-small cell lung cancer | (15) | |
| Melanoma | (15) | |
| Bladder cancer | (14) | 0.00364 |
| Neurological | ||
| Alzheimer's disease | (52) | 2.02E − 05 |
| Huntington's disease | (34) | |
| Amyotrophic lateral sclerosis (ALS) | (30) | 7.94E − 10 |
| Parkinson's disease | (27) | |
| Prion diseases | (22) | 2.26E − 08 |
| Autoimmune and atopicdiseases | ||
| Systemic lupus erythematosus | (45) | 2.48E − 06 |
| Rheumatoid arthritis | (44) | 1.26E − 12 |
| Type I diabetes mellitus | (25) | 1.11E − 08 |
| Allograft rejection | (23) | 1.56E − 09 |
| Autoimmune thyroid disease | (22) | 1.62E − 05 |
| Graft-versus-host disease | (21) | 3.63E − 06 |
| Asthma | (14) | 0.00422 |
| Primary immunodeficiency | (13) | 0.00168 |
| Cardiac | ||
| Viral myocarditis | (31) | 1.24E − 08 |
| Dilated cardiomyopathy | (27) | 0.00109 |
| Hypertrophic cardiomyopathy (HCM) | (25) | 0.00164 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | (18) | |
| Other | ||
| Alcoholism | (40) | |
| Type II diabetes mellitus | (19) | 0.00194 |
| Maturity onset diabetes of the young | (2) | |
|
| ||
| Other infections | ||
| HTLV-I infection | (85) | 1.62E − 10 |
| Tuberculosis | (80) | 6.67E − 19 |
| Influenza A | (69) | 5.11E − 14 |
| Toxoplasmosis | (66) | 6.90E − 20 |
| Herpes simplex infection | (66) | 6.88E − 12 |
| Epstein-Barr virus infection | (65) | |
| Measles | (56) | 3.36E − 13 |
| Amoebiasis | (56) | 4.59E − 13 |
| Chagas disease (American trypanosomiasis) | (55) | 2.70E − 16 |
| Pertussis | (52) | 1.38E − 20 |
| Leishmaniasis | (51) | 2.49E − 20 |
| Salmonella infection | (47) | 1.85E − 14 |
| Hepatitis C | (39) | 0.000135 |
| Legionellosis | (35) | 9.83E − 15 |
| Malaria | (32) | 2.90E − 13 |
| Shigellosis | (29) | 4.94E − 09 |
| Epithelial cell signalling in | ||
| Helicobacter pylori infection | (26) | 1.83E − 05 |
| Bacterial invasion of epithelial cells | (26) | 1.01E − 05 |
| African trypanosomiasis | (24) | 1.56E − 07 |
| Staphylococcus aureus infection | (24) | 7.63E − 07 |
| Pathogenic Escherichia coli infection | (21) | 0.000147 |
| Vibrio cholerae infection | (18) | |