Table 6.
Significantly enriched KEGG pathways within the overlapping interactome/susceptibility gene datasets (Signalling networks, metabolic pathways and neuronal pathways). P values are provided after each pathway description.
| Signalling networks | Process | Metabolism | Neuronal | |
|---|---|---|---|---|
| ADHD | Calcium signalling pathway 0.00442 | Histidine metabolism 0.000162 Tryptophan metabolism 0.000473 Phenylalanine metabolism 0.00213 Biosynthesis of unsaturated fatty acids 0.0029 Tyrosine metabolism 0.00932 |
Dopaminergic synapse 5.29E − 07 Cocaine addiction 7.07E − 07Neuroactive ligand-receptor interaction 0.000559 |
|
|
| ||||
| Autism | VEGF signalling pathway | ECM-receptor interaction 0.000918 Cell adhesion molecules (CAMs) 0.00109 Focal adhesion 0.00239 |
None | Cocaine addiction 0.000086 Amphetamine addiction 0.00061 Dopaminergic synapse 0.00203 Serotonergic synapse 0.0079 |
|
| ||||
| Anorexia | None | None | None | Dopaminergic synapse 0.0000132 Cocaine addiction 0.000019 Neuroactive ligand-receptor interaction 0.000239 Amphetamine addiction 0.00296 Morphine addiction 0.00501 Serotonergic synapse 0.00924 |
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| Childhood obesity | PPAR signalling pathway 0.000011 p53 signalling pathway 0.00822 |
None | Glycerolipid metabolism 0.00525 | None |
|
| ||||
| Depression | Calcium signalling pathway 0.000239 Circadian rhythm—mammal 0.00546 VEGF signalling pathway 0.00618 Jak-STAT signalling pathway 0.00772 TGF-beta signalling pathway 0.00877 |
Osteoclast differentiation 0.000453 Apoptosis 0.000876 Gap junction 0.00104 Melanogenesis 0.00166 |
Tryptophan metabolism 0.0000468 Arginine and proline metabolism 0.00296 Phenylalanine metabolism 0.00366 Biosynthesis of unsaturated fatty acids 0.00498 alpha-Linolenic acid metabolism 0.00498 Histidine metabolism 0.00876 |
Dopaminergic synapse 0.000000000736 Cocaine addiction 0.0000000875 Amphetamine addiction 0.00000108 Serotonergic synapse 0.0000323 Morphine addiction 0.00104 Retrograde endocannabinoid signalling 0.00155 Neuroactive ligand-receptor interaction 0.00244 Glutamatergic synapse 0.00351 Long-term depression 0.00529 |
|
| ||||
| Bipolar disorder | Calcium signalling pathway 0.000384 Jak-STAT signalling pathway 0.00121 |
Apoptosis 0.0000464 | Tyrosine metabolism 0.00306 Tryptophan metabolism 0.00354 Phenylalanine metabolism 0.00828 |
Dopaminergic synapse 0.00000000379 Cocaine addiction 0.0000000438 Amphetamine addiction 0.000000813 Neurotrophin signalling pathway 0.00292 Neuroactive ligand-receptor interaction 0.00496 |
|
| ||||
| Schizophrenia | Jak-STAT signalling pathway 0.00000299 MAPK signalling pathway 0.000558 VEGF signalling pathway 0.00077 PPAR signalling pathway 0.00395 Calcium signalling pathway 0.00444 Wnt signalling pathway 0.00661 |
Apoptosis 0.000000043 Osteoclast differentiation 0.00000285 Cell adhesion molecules (CAMs) 0.000787 |
Glutathione metabolism 0.00583 | Cocaine addiction 0.0000000151 Dopaminergic synapse 0.0000000571 Amphetamine addiction 0.00000666 Glutamatergic synapse 0.000494 Serotonergic synapse 0.00944 |
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| ||||
| Multiple sclerosis | Jak-STAT signalling pathway 0.000000000000259 TGF-beta signalling pathway 0.000492 MAPK signalling pathway 0.00126 ErbB signalling pathway 0.00382 p53 signalling pathway 0.00882 |
Osteoclast differentiation 0.000000000314 Cell adhesion molecules (CAMs) 0.0000000558 Apoptosis 0.0000000604 |
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| Alzheimer's | PPAR signalling pathway 0.0000000416 | Osteoclast differentiation 0.000351 | Terpenoid backbone biosynthesis 0.00125 Arginine and proline metabolism 0.0028 |
|
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| ||||
| Parkinson/s | MAPK signalling pathway 0.00623 | Apoptosis 0.000537 Osteoclast differentiation 0.00246 |
Arginine and proline metabolism 0.00205 Histidine metabolism 0.00684 |
Dopaminergic synapse 0.0000000876 Cocaine addiction 0.000045 Amphetamine addiction 0.0034 |