Table 4.
Comparisons Between Sitagliptin and Alogliptin in Effects on Clinical/Biochemical Parameters and Endothelial Function
| Sitagliptin | Alogliptin | P Value | |||
|---|---|---|---|---|---|
| Mean±SD | % Change From Baseline | Mean±SD | % Change From Baseline | ||
| Diabetic parameters | |||||
| Hemoglobin A1c, % | 6.55±0.44 | −4.6 | 6.69±0.56 | −3.1 | 0.126 |
| Glycated albumin, % | 16.3±1.4 | −9.4 | 16.9±2.4 | −6.7 | 0.110 |
| Fasting blood glucose, mg/dL | 116±16 | −8.5 | 118±19 | −10.3 | 0.524 |
| Serum lipids | |||||
| Total cholesterol, mg/dL | 193±36 | 0.3 | 190±31 | −3.4 | 0.060 |
| LDL cholesterol, mg/dL | 113±33 | −0.6 | 111±31 | −5.2 | 0.080 |
| HDL cholesterol, mg/dL | 55.9±13.2 | 1.8 | 53.3±11.6 | −3.8 | 0.027 |
| Triglycerides, mg/dL | 111 (98 to 136) | −10.5 | 132 (100 to 151) | 10.9 | 0.064 |
| Endothelial function | |||||
| Basal diameter before FMD, mm | 4.05±0.50 | 0.8 | 4.05±0.49 | 1.4 | 0.701 |
| Peak diameter after FMD, mm | 4.23±0.52 | −1.9 | 4.24±0.51 | −0.6 | 0.266 |
| FMD, % | 4.32±3.53 | −39.6 | 4.77±3.27 | −31.7 | 0.459 |
| Body weight, kg | 68.0±13.6 | −0.6 | 67.8±11.8 | 0.1 | 0.956 |
| Systolic blood pressure, mm Hg | 123±13 | −1.9 | 124±14 | −0.7 | 0.854 |
| Diastolic blood pressure, mm Hg | 68±10 | −5.1 | 67±9 | 0.2 | 0.653 |
| Heart rate, /min | 71±14 | 0 | 72±10 | −1.4 | 0.745 |
| Other biochemical parameters | |||||
| Immunoreactive insulin, μU/mL | 9.4±6.0 | −9.3 | 8.9±5.1 | −12.6 | 0.420 |
| DPP‐4 activity, pmol/mL per minute | 166±55 | −38.6 | 154±74 | −43.8 | 0.121 |
| GLP‐1, pmol/L | 4.14±7.91 | 139.8 | 2.38±2.39 | 14.3 | 0.045 |
| MDA‐LDL, U/L | 127±50 | 2.0 | 127±51 | 0.2 | 0.975 |
| hsCRP, mg/L | 0.64 (0.42 to 1.83) | 20.8 | 0.71 (0.36 to 1.28) | 44.9 | 0.971 |
| 8‐OHdG, ng/mL | 0.71±0.28 | 1.3 | 0.72±0.25 | −1.5 | 0.963 |
| ACR, mg/g Cr | 16.8 (8 to 66.3) | −2.9 | 10.9 (8.0 to 89.7) | −9.2 | 0.243 |
| Nitrate/nitrite, mol/L | 9.40±3.02 | 3.9 | 8.99±2.56 | −1.0 | 0.546 |
| ADMA, mol/L | 0.48±0.29 | 8.9 | 0.44±0.27 | −2.9 | 0.157 |
SD indicates, standard deviation; LDL, low‐density lipoprotein; HDL, high‐density lipoprotein; FMD, flow‐mediated vasodilatation; DPP‐4, dipeptidyl peptidase‐4; GLP‐1, glucagon‐like peptide‐1; MDA‐LDL, malondialdehyde‐modified LDL; hsCRP, high‐sensitive C‐reactive protein; 8‐OHdG, 8‐hydroxydeoxyguanosine; ACR, urinary albumin:creatinine ratio; ADMA, asymmetric dimethylarginine. Values are mean±SD except for triglycerides, hsCRP, and ACR (median [interquartile range]).