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Proposed mechanism for NO‐dependent activation of cGMP/protein kinase G (PKG) pathway by postconditioning (PoCo). The present study provides data (in red) demonstrating that PoCo attenuates the burst of O2− generated at the onset of reperfusion, reducing oxidative stress and eNOS uncoupling. NO indicates nitric oxide; ONOO−, peroxynitrite; O2−, superoxide; eNOS, endothelial nitric oxide synthase; BH4, tetrahydrobiopterin; sGC, soluble guanylyl cyclase.
