Table 2.
Mean i‐TTR by Baseline Characteristics: Medication Use
| Baseline Variable | N | i‐TTR Mean % | Univariable P Value |
|---|---|---|---|
| Prior VKA experience | <0.0001 | ||
| VKA naïve | 2596 (37) | 47.4±22.1 | |
| VKA experienced but warfarin naïve | 1334 (19) | 56.9±19.0 | |
| Warfarin experienced | 3053 (44) | 61.1±19.3 | |
| Aspirin | <0.0001 | ||
| Absence | 4949 (71) | 56.4±20.8 | |
| Presence | 2034 | 52.2±22.1 | |
| ACE inhibitor | 0.070 | ||
| Absence | 3223 | 55.7±21.3 | |
| Presence | 3760 (54) | 54.8±21.2 | |
| ACE inhibitor or ARB | 0.86 | ||
| Absence | 1808 | 55.3±21.4 | |
| Presence | 5175 (74) | 55.2±21.2 | |
| Amiodarone | <0.0001 | ||
| Absence | 6444 | 55.7±21.2 | |
| Presence | 539 (8) | 49.3±20.6 | |
| Digitalis | 0.0037 | ||
| Absence | 4278 | 55.8±21.3 | |
| Presence | 2705 (39) | 54.3±21.2 | |
| β‐Blocker | 0.0003 | ||
| Absence | 2411 | 53.9±21.8 | |
| Presence | 4572 (65) | 55.8±21.0 | |
| Loop diuretic | 0.75 | ||
| Absence | 4577 | 55.1±21.3 | |
| Presence | 2406 (34) | 55.3±21.3 | |
| Statin | <0.0001 | ||
| Absence | 3968 | 52.7±21.6 | |
| Presence | 3015 (43) | 58.4±20.3 | |
There were no missing data for this Table. i‐TTR indicates individual patient‐level time in therapeutic range; VKA, vitamin K antagonist; ACE, angiotensin‐converting enzyme; ARB, angiotensin receptor blocker.